Ketotifen fumarate is a second-generation H1-antihistamine/mast cell stabilizer. Ketotifen is also known for its effect of up-regulating the beta-2 adrenergic receptors, and can for that reason be combined with clenbuterol for treatment of especially severe asthma. Ketotifen inhibits phosphodiesterase, a chemical involved in the homeostatic feedback loop of beta-2 adrenergic activity.
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