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Pramipexole is an aminothiazole dopamine agonist with selective actions at dopamine receptors belonging to the D2 subfamily, where it possesses full activity similar to dopamine itself. By stimulating the same receptor sites as dopamine, pramipexole helps to restore dopamine activity in the brain, reducing the symptoms of Parkinson’s Disease. Experts aren't sure exactly how pramipexole works in the treatment of RLS. Pramipexole belongs to the class of medicines known as dopamine agonists.